China-US ties have become one of the bilateral relationships marked by close integration, broad cooperation and shared interests thanks to generations of concerted efforts from both sides, Wang said. These facts cannot be allowed to be denied, he added.

The differences in social systems will not and should not affect the two countries continuing to coexist peacefully and develop win-win cooperation now, Wang said, noting it's neither necessary nor possible for them to transform each other.

He said China's tremendous achievements have demonstrated that the path of socialism with Chinese characteristics not only suits its national conditions but also benefits the world.

China will continue to meet the aspirations of its people and make new and greater contributions to human development and progress, Wang said, adding that any forces who attempt to hinder or change the process will find themselves in difficulties.

Wang also stressed that the two countries should resort to cooperation instead of decoupling in developing their relations, saying both countries have benefited from their cooperation.

Wang asked that if China-US cooperation was unfair, how could it have integrated so much, developed in such broad fields and lasted for decades? He called for reforms to solve problems arising from globalization and free trade instead of shifting blame or turning to "decoupling".

He stressed that with the world economy affected by COVID-19, the world's two largest economies should develop their relationship by upholding equality and mutually beneficial cooperation and shouldering their responsibilities.

The diplomat also blamed Washington for its "troublemaking" in the South China Sea, saying the US is attempting to sow discord between China and members of the Association of Southeast Asian Nations to cater to its domestic politics and geopolitical strategy.

Wang also warned that US interference in Hong Kong affairs is intended to damage the "one country, two systems" principle and will be firmly opposed by all Chinese, including Hong Kong compatriots.