Barbra Streisand and Seth Rogen, stars of the new film "The Guilt Trip" pose as they arrive at the film's premiere in Los Angeles December 11, 2012. [Photo/Agencies]

Road-trip movies have been dominated by teenagers on wild adventures or "Hangover" style bro-mances, but Barbra Streisand and Seth Rogen are driving the genre into new territories with mother-son comedy "The Guilt Trip" to usher in the holiday season.

Photos: 'The Guilt Trip' premieres in LA

"The Guilt Trip," which hits US theaters this week, follows struggling novice inventor Andy (Seth Rogen), who is guilted in to bringing his mother on a work-related road-trip across the country.

Related:'It's a Wonderful Life' is top Christmas film with critics

Streisand, 70, who broke out as an actress in 1968's comedy "Funny Girl," returns to her comedic roots as Joyce, Andy's overbearing mother, who becomes closer to her son over the duration of their tense and comedic adventures on the road.

The actress told reporters at a recent press conference that it was her son Jason Gould who convinced her to do the project after reading the script with her, and Streisand found a deeper connection to the story.

"Mothers develop guilt trips," Streisand said. "(When my own son was young) I was working a lot and I felt guilty as a parent that I cannot pick (up) my son everyday from school, bake him cookies, that kind of thing. And so you try and compensate."

"I thought it was interesting to investigate this - trying to be his friend versus a mother...this movie, it hit on all those things that I thought I could explore."

Rogen, 30, also related closely to the mother-son storyline, saying that while he has a "good relationship" with his own mom, even she can drive him "crazy" sometimes.

"That dynamic where your mother is trying and the more she tries, the more it bugs you, the more it bugs you, the more she tries....All that is very, at times, real to my relationship with my mother," Rogen said.