Lionel Messi scored a record-tying 54th international goal as Argentina outclassed Venezuela 4-1 on Saturday to book its place in the semifinals of the Copa America Centenario.

Messi scored his fourth goal of the tournament in the 60th minute at Gillette Stadium to equal Gabriel Batistuta's long-standing Argentina international record.

Messi also set up a goal by Gonzalo Higuain, who scored twice, and one by second half substitute Erik Lamela as Argentina advanced to a semifinal against the United States in Houston on Tuesday.

Messi played down his scoring milestone.

"I'm happy for what it means and it's nice to be next to 'Batigol' (Batistuta), but for me tonight the most important thing is the result," Messi said.

Messi is determined to lead Argentina to its first trophy in 23 years after a series of agonizing near-misses, including losses in the finals of last year's Copa America and the 2014 World Cup final.

"I think people sometimes overlook that we got to two finals, and only focus on the fact we lost," Messi said.

"For us to be back in another semifinal of a big tournament like this one is a great achievement for these players."

Inspirational

Few would bet against Messi achieving his goal after an inspirational display that left Venezuela chasing shadows in the early part of Saturday's quarterfinal.

Messi's genius created the opening goal after eight minutes when he lofted a sublime curling pass to meet Higuain's run into the area.

Napoli forward Higuain still had plenty to do but adroitly directed a strike past Venezuela goalkeeper Dani Hernandez for a wonderful goal.

Argentina remained firmly in control but was jolted in the 27th minute when Nicolas Gaitan picked up a needless yellow card for a kick on Alexander Gonzalez that will see him suspended for the semifinal.

Argentina's dominance clearly had Venezuela rattled, and the Vinotinto's defensive unease led to the next goal.

A slack backpass from Arquimedes Figuera went straight to Higuain in space, and the striker coolly rounded Hernandez to stroke home his second of the night to make it 2-0 after 29 minutes.

But just when it looked as if the floodgates would open, Venezuela rallied impressively and had Argentina pinned down with a series of chances.