NASCAR Sprint Cup Series driver Danica Patrick (C) signs autographs for fans as she makes her way through the garage area after a practice session for the Daytona 500 at Daytona International Speedway in Daytona Beach, Florida February 25, 2012.??[Photo/Agencies]

Reigning NASCAR champion Tony Stewart has won just about every race ever held at the Daytona International Speedway - except for the one that really counts, the Daytona 500.

On Sunday, Stewart will be giving The Great American Race another shot up against Carl Edwards, who he tussled with for the Sprint Cup title until the final rounds of the last race of the season, and who will start on pole.

The 500, the grand opening to the NASCAR season but almost a championship in itself, has extra interest this year given the involvement of Danica Patrick, who switched from open-wheel Indy racing to become just the third female to race in the 500.

Only a Patrick victory, or perhaps a long-awaited triumph for 53-year-old Mark Martin, would cause more of a stir than Stewart finally gaining glory in the one big title that has eluded him

"I don't think we feel jinxed. We've had some really good cars here and we've just missed," Stewart, who was second in 2004 and third in 2008, said this week. "We've been leading late in these races and so I feel like (with) the law of averages, we're going to get one eventually.

Stewart, who has three Daytona wins in the 400 mile race, is a racing obsessive who drives on short circuits during NASCAR's offseason, something he tries to squeeze into his program throughout the year.

The 40-year-old has three Sprint Cups to his name as well as, in open-wheel competition, the 1997 Indy Racing League championship, but it clearly grates him that he has yet to win the big one.

"It's not a good feeling to not have that tally in the win column. Everything else we have pretty much accomplished in this sport that we want to accomplish," he said.

"It's the biggest race of the year; everyone wants to win that race. I won't say that it is not a complete career if you don't win it, but there is a lot of priority on this."

But the 500 mile race, with plenty of risk of crashes and many lead changes, often produces a surprise - last year rookie Trevor Bayne won in just his second Sprint Cup start.

Edwards, also winless in the 500, is certainly among the favorites as is Jimmie Johnson, smarting from the end of his run of five straight Sprint Cup titles and with the experience of victory at Daytona in 2006.

Jeff Gordon, a three-time winner, will be keen to prove he is not a fading force in the sport, while there is always a special level of support for Dale Earnhardt Jr. at Daytona, the site of his father's death in the 2001 race.

While NASCAR remains an almost exclusively American passion, there is some international interest in the 500 with Australian Marcus Ambrose and Colombian ex-Formula One driver Juan Pablo Montoya both in the hunt.