Philadelphia 76ers center Nerlens Noel (4) and center Jahlil Okafor (8) block the shot attempt of Cleveland Cavaliers forward LeBron James (23) during the second quarter at Wells Fargo Center in Philadelphia, Nov 2, 2015. [Photo/Agencies & Bill Streicher-USA TODAY Sports]

James, who is 20th on the all-time scoring list, could not immediately put the mark in perspective.

"It's pretty cool," he said. "I haven't had an opportunity to categorise the list of things I've done."

James did say that it was great to reach the mark in a victory while playing with a group of team mates he enjoys and, he added, "in a building that loves the game of basketball".

Cavaliers coach David Blatt called it an "extremely important, extremely impressive" mark.

"To be the youngest player in the history of the game to score 25,000 points -- particularly when you're every bit the passer that you are the scorer -- is just a testament to his greatness," Blatt said.

The Philadelphia fans accorded James with a standing ovation during a timeout with 7:45 left, when an announcement was made about his achievement.