Study: Antidepressant may lengthen life
Updated: 2007-11-23 19:35
It blocks brain cell signaling by the neurotransmitter or message-carrying chemical serotonin, which is linked with mood and appetite.
The drug is used in Europe under several brand names, including Bolvidon, Norval and Tolvon but not usually in the United States. It can cause aplastic anemia and other effects on immune system cells.
Buck's team found that in addition to interfering with serotonin in the worm, it also blocked receptors for another neurotransmitter, octopamine.
They said some other research suggests that serotonin and octopamine may complement one another -- with serotonin signaling the presence of food and octopamine signaling starvation.
Buck said it is possible that mianserin drug tips the balance in the direction of octopamine, tricking the brain into thinking it has been starved.
Petrascheck said another antidepressant, mirtazapine, had similar effects. An antihistamine and migraine drug called cyproheptadine, as well as a compound not used in people called methiothepin also affected serotonin and extended worm life span.
They tested other popular antidepressants that affect serotonin and found they did not make the worms live longer.
He is worried that people will rush to take the drugs in the hope of living longer.
"It is a stretch from a worm to a human being," Petrascheck said.
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